Molecular Insights Into Binding and Activation of the Human KCNQ2 Channel by Retigabine

Voltage-gated potassium channels of the Kv7.x family are involved in a plethora of biological processes across many tissues in animals, and their misfunctioning could lead to several pathologies ranging from diseases caused by neuronal hyperexcitability, such as epilepsy, or traumatic injuries and p...

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Bibliographic Details
Main Authors: Barbara Garofalo, Alexandre M.J.J. Bonvin, Andrea Bosin, Francesco P. Di Giorgio, Rosella Ombrato, Attilio V. Vargiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.839249/full