The Urothelial Transcriptomic Response to Interferon Gamma: Implications for Bladder Cancer Prognosis and Immunotherapy

The Urothelial Transcriptomic Response to Interferon Gamma: Implications for Bladder Cancer Prognosis and Immunotherapy

Interferon gamma (IFNγ) is central to the inflammatory immune response, such as that entrained by BCG immunotherapy for bladder cancer. However, immune-mediated tumour cell killing is subject to modulation by immunoinhibitory “checkpoint” receptors such as PD-L1. We investigated the effects of IFNγ...

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Bibliographic Details
Main Authors: Simon C. Baker, Andrew S. Mason, Raphael G. Slip, Pontus Eriksson, Gottfrid Sjödahl, Ludwik K. Trejdosiewicz, Jennifer Southgate
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
bladder cancer
urothelium
interferon gamma
BCG
immunotherapy
immune checkpoint
Online Access:https://www.mdpi.com/2072-6694/14/21/5295

Internet

https://www.mdpi.com/2072-6694/14/21/5295

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