Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus.

Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus.

Antimicrobial resistance presents a significant health care crisis. The mutation F98Y in Staphylococcus aureus dihydrofolate reductase (SaDHFR) confers resistance to the clinically important antifolate trimethoprim (TMP). Propargyl-linked antifolates (PLAs), next generation DHFR inhibitors, are much...

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Bibliographic Details
Main Authors: Siyu Wang, Stephanie M Reeve, Graham T Holt, Adegoke A Ojewole, Marcel S Frenkel, Pablo Gainza, Santosh Keshipeddy, Vance G Fowler, Dennis L Wright, Bruce R Donald
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-02-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1009855

Internet

https://doi.org/10.1371/journal.pcbi.1009855

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