Susceptibility to hypertension based on MTHFR rs1801133 single nucleotide polymorphism and MTHFR promoter methylation
BackgroundThe aetio-pathologenesis of hypertension is multifactorial, encompassing genetic, epigenetic, and environmental factors. The combined effect of genetic and epigenetic changes on hypertension is not known. We evaluated the independent and interactive association of MTHFR rs1801133 single nu...
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| Format: | Article |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1159764/full |
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| author | Ming-Huang Chiu Chia-Hsiu Chang Disline Manli Tantoh Disline Manli Tantoh Tsui-Wen Hsu Chih-Hsuan Hsiao Ji-Han Zhong Yung-Po Liaw Yung-Po Liaw Yung-Po Liaw |
| author_facet | Ming-Huang Chiu Chia-Hsiu Chang Disline Manli Tantoh Disline Manli Tantoh Tsui-Wen Hsu Chih-Hsuan Hsiao Ji-Han Zhong Yung-Po Liaw Yung-Po Liaw Yung-Po Liaw |
| author_sort | Ming-Huang Chiu |
| collection | DOAJ |
| description | BackgroundThe aetio-pathologenesis of hypertension is multifactorial, encompassing genetic, epigenetic, and environmental factors. The combined effect of genetic and epigenetic changes on hypertension is not known. We evaluated the independent and interactive association of MTHFR rs1801133 single nucleotide polymorphism (SNP) and MTHFR promoter methylation with hypertension among Taiwanese adults.MethodsWe retrieved data including, MTHFR promoter methylation, MTHFR rs1801133 genotypes (CC, CT, and TT), basic demography, personal lifestyle habits, and disease history of 1,238 individuals from the Taiwan Biobank (TWB).ResultsThe distributions of hypertension and MTHFR promoter methylation quartiles (β < 0.1338, 0.1338 ≤ β < 0.1385, 0.1385 ≤ β < 0.1423, and β ≥ 0.1423 corresponding to <Q1, Q1–Q2, Q2–Q3, and ≥Q3) among individuals with the rs1801133 genotypes (CC, CT, and TT) were significantly different (P < 0.05). The risk of hypertension was significantly higher among individuals with the TT genotype compared to the reference genotype (CC): odds ratio (OR); 95% confidence interval (CI) = 2.718; 1.503–4.914. The trend of the association of the CT and TT genotypes with hypertension was dose-dependent (P-trend = 0.0041). MTHFR promoter methylation (lower quartiles compared to ≥Q3) was not significantly associated with hypertension. However, its interaction with MTHFR rs1801133 was significant (P = 0.0323). After stratification by rs1801133 genotypes, lower MTHFR promoter methylation quartiles (<Q1, Q1–Q2, Q2–Q3) compared to ≥Q3 were significantly associated with a higher risk of hypertension among individuals carrying the CC genotype: ORs (95% CIs) = 3.225 (1.140–9.124), 4.177 (1.424–12.247), and 8.645 (2.513–29.739) for Q2–Q3, Q1–Q2, and <Q1, respectively. The trend test was significant (P-trend = 0.0009).ConclusionIndependently, rs1801133 TT was associated with a higher risk of hypertension, but methylation was not. Based on genotypes, lower methylation was dose-dependently associated with a higher risk of hypertension in individuals with the CC genotype. Our findings suggest that MTHFR rs1801133 and MTHFR promoter methylation could jointly influence hypertension susceptibility. |
| first_indexed | 2024-03-11T20:25:23Z |
| format | Article |
| id | doaj.art-760256075f564412b18a79cd98adb79d |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-11T20:25:23Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-760256075f564412b18a79cd98adb79d2023-10-02T15:36:10ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-10-011010.3389/fcvm.2023.11597641159764Susceptibility to hypertension based on MTHFR rs1801133 single nucleotide polymorphism and MTHFR promoter methylationMing-Huang Chiu0Chia-Hsiu Chang1Disline Manli Tantoh2Disline Manli Tantoh3Tsui-Wen Hsu4Chih-Hsuan Hsiao5Ji-Han Zhong6Yung-Po Liaw7Yung-Po Liaw8Yung-Po Liaw9Department of Pulmonology and Respiratory Care, Cathay General Hospital, Taipei City, TaiwanCardiovascular Center, Cathay General Hospital, Taipei City, TaiwanDepartment of Medical Imaging, Chung Shan Medical University Hospital, Taichung City, TaiwanDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, TaiwanSuperintendent Office, Institute of Medicine, Cathay General Hospital, Taipei City, TaiwanDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, TaiwanDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, TaiwanDepartment of Medical Imaging, Chung Shan Medical University Hospital, Taichung City, TaiwanDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung City, TaiwanBackgroundThe aetio-pathologenesis of hypertension is multifactorial, encompassing genetic, epigenetic, and environmental factors. The combined effect of genetic and epigenetic changes on hypertension is not known. We evaluated the independent and interactive association of MTHFR rs1801133 single nucleotide polymorphism (SNP) and MTHFR promoter methylation with hypertension among Taiwanese adults.MethodsWe retrieved data including, MTHFR promoter methylation, MTHFR rs1801133 genotypes (CC, CT, and TT), basic demography, personal lifestyle habits, and disease history of 1,238 individuals from the Taiwan Biobank (TWB).ResultsThe distributions of hypertension and MTHFR promoter methylation quartiles (β < 0.1338, 0.1338 ≤ β < 0.1385, 0.1385 ≤ β < 0.1423, and β ≥ 0.1423 corresponding to <Q1, Q1–Q2, Q2–Q3, and ≥Q3) among individuals with the rs1801133 genotypes (CC, CT, and TT) were significantly different (P < 0.05). The risk of hypertension was significantly higher among individuals with the TT genotype compared to the reference genotype (CC): odds ratio (OR); 95% confidence interval (CI) = 2.718; 1.503–4.914. The trend of the association of the CT and TT genotypes with hypertension was dose-dependent (P-trend = 0.0041). MTHFR promoter methylation (lower quartiles compared to ≥Q3) was not significantly associated with hypertension. However, its interaction with MTHFR rs1801133 was significant (P = 0.0323). After stratification by rs1801133 genotypes, lower MTHFR promoter methylation quartiles (<Q1, Q1–Q2, Q2–Q3) compared to ≥Q3 were significantly associated with a higher risk of hypertension among individuals carrying the CC genotype: ORs (95% CIs) = 3.225 (1.140–9.124), 4.177 (1.424–12.247), and 8.645 (2.513–29.739) for Q2–Q3, Q1–Q2, and <Q1, respectively. The trend test was significant (P-trend = 0.0009).ConclusionIndependently, rs1801133 TT was associated with a higher risk of hypertension, but methylation was not. Based on genotypes, lower methylation was dose-dependently associated with a higher risk of hypertension in individuals with the CC genotype. Our findings suggest that MTHFR rs1801133 and MTHFR promoter methylation could jointly influence hypertension susceptibility.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1159764/fullMTHFRpromoter methylationrs1801133hypertensionsusceptibilityinteraction |
| spellingShingle | Ming-Huang Chiu Chia-Hsiu Chang Disline Manli Tantoh Disline Manli Tantoh Tsui-Wen Hsu Chih-Hsuan Hsiao Ji-Han Zhong Yung-Po Liaw Yung-Po Liaw Yung-Po Liaw Susceptibility to hypertension based on MTHFR rs1801133 single nucleotide polymorphism and MTHFR promoter methylation Frontiers in Cardiovascular Medicine MTHFR promoter methylation rs1801133 hypertension susceptibility interaction |
| title | Susceptibility to hypertension based on MTHFR rs1801133 single nucleotide polymorphism and MTHFR promoter methylation |
| title_full | Susceptibility to hypertension based on MTHFR rs1801133 single nucleotide polymorphism and MTHFR promoter methylation |
| title_fullStr | Susceptibility to hypertension based on MTHFR rs1801133 single nucleotide polymorphism and MTHFR promoter methylation |
| title_full_unstemmed | Susceptibility to hypertension based on MTHFR rs1801133 single nucleotide polymorphism and MTHFR promoter methylation |
| title_short | Susceptibility to hypertension based on MTHFR rs1801133 single nucleotide polymorphism and MTHFR promoter methylation |
| title_sort | susceptibility to hypertension based on mthfr rs1801133 single nucleotide polymorphism and mthfr promoter methylation |
| topic | MTHFR promoter methylation rs1801133 hypertension susceptibility interaction |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1159764/full |
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