Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition
Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal-plasticity and is dependent on dynamic microtubules. Histone-deacetylase-6 (HDAC6) decreases microtubule dynamics by...
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-04-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/63076 |