Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition

Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition

Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are related neurodegenerative diseases that belong to a common disease spectrum based on overlapping clinical, pathological and genetic evidence. Early pathological changes to the morphology and synapses of affected neuro...

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Bibliographic Details
Main Authors: Mari Carmen Pelaez, Antoine Desmeules, Pauline A. Gelon, Bastien Glasson, Laetitia Marcadet, Alicia Rodgers, Daniel Phaneuf, Silvia Pozzi, Paul A. Dutchak, Jean-Pierre Julien, Chantelle F. Sephton
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis (ALS)
Frontotemporal dementia (FTD)
Motor neuron disease (MND)
Synapse
Dendrite
Synaptopathy
Online Access:https://doi.org/10.1186/s40478-023-01671-1

Internet

https://doi.org/10.1186/s40478-023-01671-1

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