Column chromatography USED in purification of genotoxic impurity sample of imatinib mesylate substance

Column chromatography USED in purification of genotoxic impurity sample of imatinib mesylate substance

The article describes a simple method for purifying N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine for further use as a standard for quantitative determination of genotoxic impurities substance imatinib mesylate. Experimentally proved choice of sorbent used for purification of N-(5-amino...

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Bibliographic Details
Main Authors: V. I. Krylov, S. V. Moiseev, O. V. Knyazkina, V. A. Yashkir, V. A. Merkulov
Format: Article
Language:Russian
Published: NEICON ISP LLC 2018-02-01
Series:Ведомости Научного центра экспертизы средств медицинского применения
Subjects:
n-(5-амино-2-метилфенил)-4-(3-пиридил)-2-пиримидинамин
иматиниба мезилат
генотоксичная примесь
колоночная хроматография
нейтральный оксид алюминия
вэжх
спектроскопия ямр
n-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine
imatinib mesylate
genotoxic impurity
column chromatography
neutral alumina
hplc
nmr spectroscopy
Online Access:https://www.vedomostincesmp.ru/jour/article/view/91

Internet

https://www.vedomostincesmp.ru/jour/article/view/91

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