Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43266-283

Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43266-283

Background: Glioblastoma is the most aggressive primary brain tumour and has a very poor prognosis. Inhibition of c-Src activity in glioblastoma stem cells (GSCs, responsible for glioblastoma lethality) and primary glioblastoma cells by the peptide TAT-Cx43266–283 reduces tumorigenicity, and boosts...

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Bibliographic Details
Main Authors: Sara G. Pelaz, Myriam Jaraíz-Rodríguez, Andrea Álvarez-Vázquez, Rocío Talaverón, Laura García-Vicente, Raquel Flores-Hernández, Marta Gómez de Cedrón, María Tabernero, Ana Ramírez de Molina, Concepción Lillo, José M. Medina, Arantxa Tabernero
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:EBioMedicine
Subjects:
Cancer metabolism
Brain tumour
Connexin
Glioblastoma stem cells
GLUT-3
Hexokinase-2
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420305107

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http://www.sciencedirect.com/science/article/pii/S2352396420305107

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