Obesity-Linked PPARγ Ser273 Phosphorylation Promotes Beneficial Effects on the Liver, despite Reduced Insulin Sensitivity in Mice

Obesity-Linked PPARγ Ser273 Phosphorylation Promotes Beneficial Effects on the Liver, despite Reduced Insulin Sensitivity in Mice

Since the removal of thiazolidinediones (TZDs) from the market, researchers have been exploring alternative anti-diabetic drugs that target PPARγ without causing adverse effects while promoting insulin sensitization by blocking serine 273 phosphorylation (Ser273 or S273). Nonetheless, the underlying...

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Bibliographic Details
Main Authors: Maiara Ferreira Terra, Marta García-Arévalo, Thayná Mendonça Avelino, Karina Y. Degaki, Murilo de Carvalho, Felipe Rafael Torres, Angela Saito, Ana Carolina Migliorini Figueira
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomolecules
Subjects:
insulin sensitization
PPAR
PPAR phosphorylation
type 2 diabetes
Online Access:https://www.mdpi.com/2218-273X/13/4/632

Internet

https://www.mdpi.com/2218-273X/13/4/632

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