Using Gene Essentiality and Synthetic Lethality Information to Correct Yeast and CHO Cell Genome-Scale Models

Using Gene Essentiality and Synthetic Lethality Information to Correct Yeast and CHO Cell Genome-Scale Models

Essentiality (ES) and Synthetic Lethality (SL) information identify combination of genes whose deletion inhibits cell growth. This information is important for both identifying drug targets for tumor and pathogenic bacteria suppression and for flagging and avoiding gene deletions that are non-viable...

Full description

Bibliographic Details
Main Authors: Ratul Chowdhury, Anupam Chowdhury, Costas D. Maranas
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Metabolites
Subjects:
synthetic lethality
yeast
Chinese Hamster Ovary
model curation
Online Access:http://www.mdpi.com/2218-1989/5/4/536

Internet

http://www.mdpi.com/2218-1989/5/4/536

Similar Items