Design and Synthesis of (2-<i>oxo</i>-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents

Design and Synthesis of (2-<i>oxo</i>-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents

A mild and versatile method based on Cu-catalyzed [2+3] cycloaddition (Huisgen-Meldal-Sharpless reaction) was developed to tether 3,3’-((4-(prop-2-yn-1-yloxy)phenyl)methylene)<i>bis</i>(4-hydroxyquinolin-2(1<i>H</i>)-ones) with 4-azido-2-quinolones in good yields. This method...

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Bibliographic Details
Main Authors: Essmat M. El-Sheref, Mohammed A. I. Elbastawesy, Alan B. Brown, Ahmed M. Shawky, Hesham A. M. Gomaa, Stefan Bräse, Bahaa G. M. Youssif
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
click
azido
quinolones
triazole
anti-proliferative
apoptosis
Online Access:https://www.mdpi.com/1420-3049/26/22/6798

Internet

https://www.mdpi.com/1420-3049/26/22/6798

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