Clinical features and mutational analysis of X-linked agammaglobulinemia patients in Malaysia

Clinical features and mutational analysis of X-linked agammaglobulinemia patients in Malaysia

BackgroundBruton’s tyrosine kinase (BTK) is a cytoplasmic protein involved in the B cell development. X-linked agammaglobulinemia (XLA) is caused by mutation in the BTK gene, which results in very low or absent B cells. Affected males have markedly reduced immunoglobulin levels, which render them su...

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Bibliographic Details
Main Authors: Chai Teng Chear, Intan Hakimah Ismail, Kwai Cheng Chan, Lokman Mohd Noh, Asiah Kassim, Amir Hamzah Abdul Latiff, Sandeep Singh Gill, Nazatul Haslina Ramly, Kah Kee Tan, Charlotte Sundaraj, Chong Ming Choo, Sharifah Adlena Syed Mohamed, Mohd Farid Baharin, Amelia Suhana Zamri, Sharifah Nurul Husna Syed Yahya, Saharuddin Bin Mohamad, Adiratna Mat Ripen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
X-linked agammaglobulinemia
XLA
Bruton’s tyrosine kinase
BTK protein
BTK mutation
de novo mutation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1252765/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1252765/full

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