Regulatory CD4+ T cells redirected against pathogenic CD8+ T cells protect NOD mice from development of autoimmune diabetes

Regulatory CD4+ T cells redirected against pathogenic CD8+ T cells protect NOD mice from development of autoimmune diabetes

IntroductionIn this study, we report a novel therapeutic approach redirecting antigen-specific CD4+ T cells recognizing a hybrid insulin peptide (BDC2.5 T cell receptor (TCR) transgenic CD4+ T cells) to attract and suppress islet-specific CD8+ T cells T cells in the non-obese diabetic (NOD) mouse mo...

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Bibliographic Details
Main Authors: Dimitri Kakabadse, Dawei Chen, Sigal Fishman, Hadas Weinstein-Marom, Joanne Davies, Li Wen, Gideon Gross, F. Susan Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Immunology
Subjects:
NOD mice
type 1 diabetes
CD8 + T cells
CAR (chimeric antigen receptor) Treg cell therapy
antigen-specific regulatory T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1463971/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1463971/full

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