Mouse myofibers lacking the SMYD1 methyltransferase are susceptible to atrophy, internalization of nuclei and myofibrillar disarray

Mouse myofibers lacking the SMYD1 methyltransferase are susceptible to atrophy, internalization of nuclei and myofibrillar disarray

The Smyd1 gene encodes a lysine methyltransferase specifically expressed in striated muscle. Because Smyd1-null mouse embryos die from heart malformation prior to formation of skeletal muscle, we developed a Smyd1 conditional-knockout allele to determine the consequence of SMYD1 loss in mammalian sk...

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Bibliographic Details
Main Authors: M. David Stewart, Suhujey Lopez, Harika Nagandla, Benjamin Soibam, Ashley Benham, Jasmine Nguyen, Nicolas Valenzuela, Harry J. Wu, Alan R. Burns, Tara L. Rasmussen, Haley O. Tucker, Robert J. Schwartz
Format: Article
Language:English
Published: The Company of Biologists 2016-03-01
Series:Disease Models & Mechanisms
Subjects:
Genetics
Development
Muscle
Myocyte
SMYD1
Methylation
Myopathy
Online Access:http://dmm.biologists.org/content/9/3/347

Internet

http://dmm.biologists.org/content/9/3/347

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