A reporter gene assay for determining the biological activity of therapeutic antibodies targeting TIGIT

A reporter gene assay for determining the biological activity of therapeutic antibodies targeting TIGIT

T cell immunoglobulin and ITIM domain (TIGIT) is a novel immune checkpoint that has been considered as a target in cancer immunotherapy. Current available bioassays for measuring the biological activity of therapeutic antibodies targeting TIGIT are restricted to mechanistic investigations because do...

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Bibliographic Details
Main Authors: Zhihao Fu, Hongchuan Liu, Lan Wang, Chuanfei Yu, Yalan Yang, Meiqing Feng, Junzhi Wang
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
TIGIT
Therapeutic antibodies
Bioactivity determination
Reporter gene assay
Method validation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521003531

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http://www.sciencedirect.com/science/article/pii/S2211383521003531

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