Tanshinone IIA Inhibits Epithelial-to-Mesenchymal Transition Through Hindering β-Arrestin1 Mediated β-Catenin Signaling Pathway in Colorectal Cancer

Tanshinone IIA Inhibits Epithelial-to-Mesenchymal Transition Through Hindering β-Arrestin1 Mediated β-Catenin Signaling Pathway in Colorectal Cancer

Tanshinone IIA (Tan IIA) is a major active ingredient extracted from Salvia miltiorrhiza, which has been proved to be able to inhibit metastasis of various cancers including colorectal cancer (CRC). However, the mechanisms of anti-metastatic effect of Tan IIA on CRC are not well explored. A number o...

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Bibliographic Details
Main Authors: Qing Song, Liu Yang, Zhifen Han, Xinnan Wu, Ruixiao Li, Lihong Zhou, Ningning Liu, Hua Sui, Jianfeng Cai, Yan Wang, Qing Ji, Qi Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
tanshinone IIA
colorectal cancer
epithelial-to-mesenchymal transition
β-arrestin1
β-catenin signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.586616/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.586616/full

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