Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices

Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices

Microglial cells have emerged as crucial players in synaptic plasticity during development and adulthood, and also in neurodegenerative and neuroinflammatory conditions. Here we found that decreased levels of Sirtuin 2 (Sirt2) deacetylase in microglia affects hippocampal synaptic plasticity under in...

Full description

Bibliographic Details
Main Authors: Joana Sa de Almeida, Mariana Vargas, João Fonseca-Gomes, Sara Ramalho Tanqueiro, Rita F. Belo, Catarina Miranda-Lourenço, Ana M. Sebastião, Maria José Diógenes, Teresa F. Pais
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroscience
Subjects:
sirtuin 2
long-term potentiation
microglia
neuroinfalmmation
memantine
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00614/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00614/full

Similar Items