Investigating In Vitro and Ex Vivo Properties of Artemether/Lumefantrine Double-Fixed Dose Combination Lipid Matrix Tablets Prepared by Hot Fusion

Investigating In Vitro and Ex Vivo Properties of Artemether/Lumefantrine Double-Fixed Dose Combination Lipid Matrix Tablets Prepared by Hot Fusion

Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden, are therapeutically hindered by low aqueous solubility and varied bioavailability. This work investigates the plausibility of directly compres...

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Bibliographic Details
Main Authors: Christi A. Wilkins, Lissinda H. du Plessis, Joe M. Viljoen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
artemether
lumefantrine
lipid-based formulations
solid lipid dispersion
hot fusion
double-fixed dose combination
Online Access:https://www.mdpi.com/1999-4923/13/7/922

Internet

https://www.mdpi.com/1999-4923/13/7/922

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