IFN-γ blockade after genetic inhibition of PD-1 aggravates skeletal muscle damage and impairs skeletal muscle regeneration

IFN-γ blockade after genetic inhibition of PD-1 aggravates skeletal muscle damage and impairs skeletal muscle regeneration

Abstract Background Innate immune responses play essential roles in skeletal muscle recovery after injury. Programmed cell death protein 1 (PD-1) contributes to skeletal muscle regeneration by promoting macrophage proinflammatory to anti-inflammatory phenotype transition. Interferon (IFN)-γ induces...

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Bibliographic Details
Main Authors: Shuzhao Zhuang, Aaron Russell, Yifan Guo, Yingying Xu, Weihua Xiao
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Cellular & Molecular Biology Letters
Subjects:
Skeletal muscle
Macrophage
Neutrophil
PD-1
IFN-γ
Online Access:https://doi.org/10.1186/s11658-023-00439-8

Internet

https://doi.org/10.1186/s11658-023-00439-8

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