Synthesis of Norabietyl and Nordehydroabietyl Imidazolidine-2,4,5-Triones and Their Activity against Tyrosyl-DNA Phosphodiesterase 1

Synthesis of Norabietyl and Nordehydroabietyl Imidazolidine-2,4,5-Triones and Their Activity against Tyrosyl-DNA Phosphodiesterase 1

New imidazolidine-2,4,5-triones with norabietic, nordehydroabietic, and adamantane substituents were synthesized by reacting oxalyl chloride and the corresponding ureas, providing good yields. Bioisosteric replacement of the ureide group with a parabanic acid fragment made it possible to increase th...

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Bibliographic Details
Main Authors: Kseniya S. Kovaleva, Olga I. Yarovaya, Irina A. Chernyshova, Alexandra L. Zakharenko, Sergey V. Cheresiz, Amirhossein Azimirad, Andrey G. Pokrovsky, Olga I. Lavrik, Nariman F. Salakhutdinov
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molbank
Subjects:
resin acids
TDP1 inhibitors
heterocyclic compounds
DNA repair
parabanic acid
adamantane
Online Access:https://www.mdpi.com/1422-8599/2023/4/M1743

Internet

https://www.mdpi.com/1422-8599/2023/4/M1743

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