AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology

AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology

Abstract Background Skeletomuscular diseases result in significant muscle loss and decreased performance, paralleled by a loss in mitochondrial and oxidative capacity. Insulin and insulin‐like growth factor‐1 (IGF‐1) are two potent anabolic hormones that activate a host of signalling intermediates i...

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Bibliographic Details
Main Authors: Natasha Jaiswal, Matthew Gavin, Emanuele Loro, Jaimarie Sostre‐Colón, Paul A. Roberson, Kahealani Uehara, Nicole Rivera‐Fuentes, Michael Neinast, Zoltan Arany, Scot R. Kimball, Tejvir S. Khurana, Paul M. Titchenell
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
AKT signalling
Disuse‐induced muscle wasting
Fibre specification
Insulin action
Online Access:https://doi.org/10.1002/jcsm.12846

Internet

https://doi.org/10.1002/jcsm.12846

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