Circulating RAC1 contributed to steroid-sensitive nephrotic syndrome: Mendelian randomization, single-cell RNA-sequencing, proteomic, and experimental evidence

Circulating RAC1 contributed to steroid-sensitive nephrotic syndrome: Mendelian randomization, single-cell RNA-sequencing, proteomic, and experimental evidence

Objectives The small GTPase Rac1 (RAC1) has been linked to podocyte disorders and steroid-sensitive nephrotic syndrome (SSNS). The aim of this study was to explore and validate the potential causal association between circulating RAC1 and SSNS.Methods The association between circulating RAC1 and SSN...

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Bibliographic Details
Main Authors: Yi Zhang, Tianwen Yao, Yanqiu Xu, Yi Wang, Shisheng Han
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
RAC1
steroid-sensitive nephrotic syndrome
podocyte
Mendelian randomization
single-cell RNA-sequencing, proteomic analysis
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2416087

Internet

https://www.tandfonline.com/doi/10.1080/0886022X.2024.2416087

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