Transduction catalysis: Doxorubicin amplifies rAAV-mediated gene expression in the cortex of higher-order vertebrates

Transduction catalysis: Doxorubicin amplifies rAAV-mediated gene expression in the cortex of higher-order vertebrates

Summary: Rapid and efficient gene transduction via recombinant adeno-associated viruses (rAAVs) is highly desirable across many basic and clinical research domains. Here, we report that vector co-infusion with doxorubicin, a clinical anti-cancer drug, markedly enhanced rAAV-mediated transgene expres...

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Bibliographic Details
Main Authors: Hongliang Gong, Nini Yuan, Zhiming Shen, Cheng Tang, Stewart Shipp, Liling Qian, Yiliang Lu, Ian Max Andolina, Shenghai Zhang, Jihong Wu, Hui Yang, Wei Wang
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
Molecular biology
Neuroscience
Molecular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221006532

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221006532

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