A high-salt diet promotes hypertrophic scarring through TRPC3-mediated mitochondrial Ca2+ homeostasis dysfunction

A high-salt diet promotes hypertrophic scarring through TRPC3-mediated mitochondrial Ca2+ homeostasis dysfunction

Diet High in salt content have been associated with cardiovascular disease and chronic inflammation. We recently demonstrated that transient receptor potential canonical 3 (TRPC3) channels regulate myofibroblast transdifferentiation in hypertrophic scars. Here, we examined how high salt activation o...

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Bibliographic Details
Main Authors: Weijie Xia, Qianran Wang, Shaoyang Lin, Yuanyuan Wang, Junbo Zhang, Hailin Wang, Xia Yang, Yingru Hu, Huaping Liang, Yuangang Lu, Zhiming Zhu, Daoyan Liu
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Heliyon
Subjects:
High salt
TRPC3
ROS
Hypertrophic scar
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023058371

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http://www.sciencedirect.com/science/article/pii/S2405844023058371

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