Myth or Truth: The Glass Forming Ability Class III Drugs Will Always Form Single-Phase Homogenous Amorphous Solid Dispersion Formulations

Myth or Truth: The Glass Forming Ability Class III Drugs Will Always Form Single-Phase Homogenous Amorphous Solid Dispersion Formulations

The physical stability of amorphous solid dispersions (ASD) of active pharmaceutical ingredients (APIs) of high glass forming ability (GFA class III) is generally expected to be high among the scientific community. In this study, the ASD of ten-selected class III APIs with the two polymers, PVPVA 64...

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Bibliographic Details
Main Authors: Piyush Panini, Massimiliano Rampazzo, Abhishek Singh, Filip Vanhoutte, Guy Van den Mooter
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Pharmaceutics
Subjects:
amorphous solid dispersion
glass forming ability
gfa classification
glass transition
apis
spray-drying
film-casting
mdsc
pxrd
Online Access:https://www.mdpi.com/1999-4923/11/10/529

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https://www.mdpi.com/1999-4923/11/10/529

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