Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex

Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex

Here the authors probe the cleavage and gate opening of single-stranded DNA by the human topoisomerase TRR using a unique single-molecule strategy to reveal structural plasticity in response to both double-stranded DNA and the helicase BLM.

Bibliographic Details
Main Authors: Julia A. M. Bakx, Andreas S. Biebricher, Graeme A. King, Panagiotis Christodoulis, Kata Sarlós, Anna H. Bizard, Ian D. Hickson, Gijs J. L. Wuite, Erwin J. G. Peterman
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28082-5

Internet

https://doi.org/10.1038/s41467-022-28082-5

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