Detection of Ki67 Hot-Spots of Invasive Breast Cancer Based on Convolutional Neural Networks Applied to Mutual Information of H&E and Ki67 Whole Slide Images

Detection of Ki67 Hot-Spots of Invasive Breast Cancer Based on Convolutional Neural Networks Applied to Mutual Information of H&E and Ki67 Whole Slide Images

Ki67 hot-spot detection and its evaluation in invasive breast cancer regions play a significant role in routine medical practice. The quantification of cellular proliferation assessed by Ki67 immunohistochemistry is an established prognostic and predictive biomarker that determines the choice of the...

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Bibliographic Details
Main Authors: Zaneta Swiderska-Chadaj, Jaime Gallego, Lucia Gonzalez-Lopez, Gloria Bueno
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Applied Sciences
Subjects:
Ki67 hot-spot detection
Ki67 labeling index
proliferation index
CNNs
color deconvolution
WSI
Online Access:https://www.mdpi.com/2076-3417/10/21/7761

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