Bystander Effects of Hypoxia-Activated Prodrugs: Agent-Based Modeling Using Three Dimensional Cell Cultures

Bystander Effects of Hypoxia-Activated Prodrugs: Agent-Based Modeling Using Three Dimensional Cell Cultures

Intra-tumor heterogeneity represents a major barrier to anti-cancer therapies. One strategy to minimize this limitation relies on bystander effects via diffusion of cytotoxins from targeted cells. Hypoxia-activated prodrugs (HAPs) have the potential to exploit hypoxia in this way, but robust methods...

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Bibliographic Details
Main Authors: Cho R. Hong, Gib Bogle, Jingli Wang, Kashyap Patel, Frederik B. Pruijn, William R. Wilson, Kevin O. Hicks
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
hypoxia-activated prodrugs
agent-based modeling
PKPD models
bystander effects
multicellular spheroids
PR104A
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01013/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01013/full

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