Lipidomics and H218O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos

Lipidomics and H218O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos

We hypothesized that vitamin E (α-tocopherol) is required by the developing embryonic brain to prevent depletion of highly polyunsaturated fatty acids, especially docosahexaenoic acid (DHA, 22:6), the loss of which we predicted would underlie abnormal morphological and behavioral outcomes. Therefore...

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Bibliographic Details
Main Authors: Melissa Q. McDougall, Jaewoo Choi, Jan F. Stevens, Lisa Truong, Robert L. Tanguay, Maret G. Traber
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Redox Biology
Subjects:
Brain
Development
Docosahexaenoic acid
H218O
Peroxidation
Vitamin E
Mass spectrometry
Phospholipids
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716300064

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http://www.sciencedirect.com/science/article/pii/S2213231716300064

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