Synthesis, testing, and computational modeling of pleuromutilin 1,2,3-triazole derivatives in the ribosome

Synthesis, testing, and computational modeling of pleuromutilin 1,2,3-triazole derivatives in the ribosome

Pleuromutilin antimicrobials have given rise to the most recently FDA approved class of antibiotics for systemic human use. In this work, we describe a synthesis, assay, modeling approach to pleuromutilin development for the highly complex bacterial ribosome. Libraries of substituted 1,2,3-triazole...

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Bibliographic Details
Main Authors: Logan M. Breiner, Anthony J. Briganti, Jennifer P. McCord, Moriah E. Heifetz, Sophia Y. Philbrook, Carla Slebodnick, Anne M. Brown, Andrew N. Lowell
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Tetrahedron Chem
Subjects:
Ribosome
Antibiotics
Pleuromutilin
Click-chemistry
In silico modeling
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2666951X22000304

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http://www.sciencedirect.com/science/article/pii/S2666951X22000304

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