17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α

17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α

UDP-glucuronosyltransferase 1A9 (UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous molecules. Clinical data have shown increased elimination of UGT1A9 substrates in pregnant women or oral contraceptive users, but the role of estrogen in the regulation of UGT1A9 e...

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Bibliographic Details
Main Authors: Sung-joon Cho, Miaoran Ning, Yanyan Zhang, Leah H. Rubin, Hyunyoung Jeong
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
UGT1A9
17β-Estradiol
Estrogen receptor
Drug metabolism
Sex difference
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383516300119

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http://www.sciencedirect.com/science/article/pii/S2211383516300119

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