Rivaroxaban, a Direct Factor Xa Inhibitor, Ameliorates Hypertensive Renal Damage Through Inhibition of the Inflammatory Response Mediated by Protease‐Activated Receptor Pathway

Rivaroxaban, a Direct Factor Xa Inhibitor, Ameliorates Hypertensive Renal Damage Through Inhibition of the Inflammatory Response Mediated by Protease‐Activated Receptor Pathway

Background An enhanced renin‐angiotensin system causes hypertensive renal damage. Factor Xa not only functions in the coagulation cascade but also activates intracellular signaling through protease‐activated receptors (PAR). We investigated the effects of rivaroxaban, a factor Xa inhibitor, on hyper...

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Bibliographic Details
Main Authors: Hiroaki Ichikawa, Michiko Shimada, Masato Narita, Ikuyo Narita, Yoshihiro Kimura, Makoto Tanaka, Tomohiro Osanai, Ken Okumura, Hirofumi Tomita
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
albuminuria
podocytes
protease‐activated receptor‐2
renin‐angiotensin system
rivaroxaban
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.012195

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.012195

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