Quinoa (Chenopodium quinoa Willd.) supplemented cafeteria diet ameliorates glucose intolerance in rats
Abstract Quinoa (Chenopodium quinoa Willd.) is a pseudocereal with rich nutritional composition, gluten free, and organoleptic. The primary aim of this study was to elucidate the possible protective roles of quinoa in glucose homeostasis in a model of cafeteria diet‐induced obesity. Male Wistar rats...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-11-01
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| Series: | Food Science & Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/fsn3.3603 |
| _version_ | 1797633804539527168 |
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| author | Hatice Ozcaliskan Ilkay Derya Karabulut Gonca Kamaci Ozocak Ecmel Mehmetbeyoglu Emin Kaymak Betul Kisioglu Betul Cicek Asli Akyol |
| author_facet | Hatice Ozcaliskan Ilkay Derya Karabulut Gonca Kamaci Ozocak Ecmel Mehmetbeyoglu Emin Kaymak Betul Kisioglu Betul Cicek Asli Akyol |
| author_sort | Hatice Ozcaliskan Ilkay |
| collection | DOAJ |
| description | Abstract Quinoa (Chenopodium quinoa Willd.) is a pseudocereal with rich nutritional composition, gluten free, and organoleptic. The primary aim of this study was to elucidate the possible protective roles of quinoa in glucose homeostasis in a model of cafeteria diet‐induced obesity. Male Wistar rats (3 weeks of age) were randomly allocated to be fed by; control chow (CON; n = 6), quinoa (QUI; n = 6), cafeteria (CAF; n = 6), or quinoa and cafeteria (CAFQ; n = 6) for 15 weeks. CAFQ resulted in decreased saturated fat, sugar, and sodium intake in comparison with CAF. Compared to CON, CAF increased body weight gain, plasma insulin, plasma glucose, decreased liver IRS‐1, AMPK mRNA expressions, and pancreatic β‐cell insulin immunoreactivity, and developed hepatocyte degeneration and microvesicular steatosis. Compared to CAF, QUI lowered body weight, plasma glucose, and plasma insulin, increased liver IRS‐1 and AMPK mRNA expressions, and pancreatic β‐cell insulin immunoreactivity. Compared to CAF, CAFQ lowered plasma glucose, increased liver IRS‐1 mRNA expressions, increased pancreatic β‐cell insulin immunoreactivity, and lowered hepatocyte degeneration and microvesicular steatosis. Dietary treatments did not influence IRS‐2, AKT2, and INSR mRNA expressions. HOMA‐IR, HOMA‐β, and QUICKI were also similar between groups. Restoration of insulin in CAFQ islets was as well as that of CON and QUI groups. In conclusion, as a functional food, quinoa may be useful in the prevention of obesity and associated metabolic outcomes such as glucose intolerance, disrupted pancreatic β‐cell function, hepatic insulin resistance, and lipid accumulation. |
| first_indexed | 2024-03-11T11:58:46Z |
| format | Article |
| id | doaj.art-76579bfcf501475b98aa885cf9ff741d |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-03-11T11:58:46Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-76579bfcf501475b98aa885cf9ff741d2023-11-08T09:39:18ZengWileyFood Science & Nutrition2048-71772023-11-0111116920693010.1002/fsn3.3603Quinoa (Chenopodium quinoa Willd.) supplemented cafeteria diet ameliorates glucose intolerance in ratsHatice Ozcaliskan Ilkay0Derya Karabulut1Gonca Kamaci Ozocak2Ecmel Mehmetbeyoglu3Emin Kaymak4Betul Kisioglu5Betul Cicek6Asli Akyol7Faculty of Health Sciences, Department of Nutrition and Dietetics Hacettepe University Ankara TurkeyFaculty of Medicine, Department of Histology and Embryology Erciyes University Kayseri TurkeyFaculty of Veterinary Medicine, Department of Laboratory Animals Science Erciyes University Kayseri TurkeyErciyes University Betul Ziya Eren Genome and Stem Cell Center Kayseri TurkeyFaculty of Medicine, Department of Histology and Embryology Yozgat Bozok University Yozgat TurkeyFaculty of Health Sciences, Department of Nutrition and Dietetics Hacettepe University Ankara TurkeyFaculty of Health Sciences, Department of Nutrition and Dietetics Erciyes University Kayseri TurkeyFaculty of Health Sciences, Department of Nutrition and Dietetics Hacettepe University Ankara TurkeyAbstract Quinoa (Chenopodium quinoa Willd.) is a pseudocereal with rich nutritional composition, gluten free, and organoleptic. The primary aim of this study was to elucidate the possible protective roles of quinoa in glucose homeostasis in a model of cafeteria diet‐induced obesity. Male Wistar rats (3 weeks of age) were randomly allocated to be fed by; control chow (CON; n = 6), quinoa (QUI; n = 6), cafeteria (CAF; n = 6), or quinoa and cafeteria (CAFQ; n = 6) for 15 weeks. CAFQ resulted in decreased saturated fat, sugar, and sodium intake in comparison with CAF. Compared to CON, CAF increased body weight gain, plasma insulin, plasma glucose, decreased liver IRS‐1, AMPK mRNA expressions, and pancreatic β‐cell insulin immunoreactivity, and developed hepatocyte degeneration and microvesicular steatosis. Compared to CAF, QUI lowered body weight, plasma glucose, and plasma insulin, increased liver IRS‐1 and AMPK mRNA expressions, and pancreatic β‐cell insulin immunoreactivity. Compared to CAF, CAFQ lowered plasma glucose, increased liver IRS‐1 mRNA expressions, increased pancreatic β‐cell insulin immunoreactivity, and lowered hepatocyte degeneration and microvesicular steatosis. Dietary treatments did not influence IRS‐2, AKT2, and INSR mRNA expressions. HOMA‐IR, HOMA‐β, and QUICKI were also similar between groups. Restoration of insulin in CAFQ islets was as well as that of CON and QUI groups. In conclusion, as a functional food, quinoa may be useful in the prevention of obesity and associated metabolic outcomes such as glucose intolerance, disrupted pancreatic β‐cell function, hepatic insulin resistance, and lipid accumulation.https://doi.org/10.1002/fsn3.3603cafeteria dietglucose toleranceobesityquinoarats |
| spellingShingle | Hatice Ozcaliskan Ilkay Derya Karabulut Gonca Kamaci Ozocak Ecmel Mehmetbeyoglu Emin Kaymak Betul Kisioglu Betul Cicek Asli Akyol Quinoa (Chenopodium quinoa Willd.) supplemented cafeteria diet ameliorates glucose intolerance in rats Food Science & Nutrition cafeteria diet glucose tolerance obesity quinoa rats |
| title | Quinoa (Chenopodium quinoa Willd.) supplemented cafeteria diet ameliorates glucose intolerance in rats |
| title_full | Quinoa (Chenopodium quinoa Willd.) supplemented cafeteria diet ameliorates glucose intolerance in rats |
| title_fullStr | Quinoa (Chenopodium quinoa Willd.) supplemented cafeteria diet ameliorates glucose intolerance in rats |
| title_full_unstemmed | Quinoa (Chenopodium quinoa Willd.) supplemented cafeteria diet ameliorates glucose intolerance in rats |
| title_short | Quinoa (Chenopodium quinoa Willd.) supplemented cafeteria diet ameliorates glucose intolerance in rats |
| title_sort | quinoa chenopodium quinoa willd supplemented cafeteria diet ameliorates glucose intolerance in rats |
| topic | cafeteria diet glucose tolerance obesity quinoa rats |
| url | https://doi.org/10.1002/fsn3.3603 |
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