Template-Based de Novo Design for Type II Kinase Inhibitors and Its Extented Application to Acetylcholinesterase Inhibitors

Template-Based de Novo Design for Type II Kinase Inhibitors and Its Extented Application to Acetylcholinesterase Inhibitors

There is a compelling need to discover type II inhibitors targeting the unique DFG-out inactive kinase conformation since they are likely to possess greater potency and selectivity relative to traditional type I inhibitors. Using a known inhibitor, such as a currently available and approved drug or...

Full description

Bibliographic Details
Main Authors: Bo-Han Su, Yi-Syuan Huang, Chia-Yun Chang, Yi-Shu Tu, Yufeng J. Tseng
Format: Article
Language:English
Published: MDPI AG 2013-10-01
Series:Molecules
Subjects:
template-based
de novo design
group efficiency
type II kinase inhibitors
lead optimization
AChE inhibitors
Online Access:http://www.mdpi.com/1420-3049/18/11/13487

Internet

http://www.mdpi.com/1420-3049/18/11/13487

Similar Items