The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases

The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases

Abstract Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, accompanied by amyloid-β (Aβ) overload and hyperphosphorylated tau accumulation in the brain. Synaptic dysfunction, an important pathological hallmark in AD, is recognized as the main cau...

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Bibliographic Details
Main Authors: Moxin Wu, Manqing Zhang, Xiaoping Yin, Kai Chen, Zhijian Hu, Qin Zhou, Xianming Cao, Zhiying Chen, Dan Liu
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Translational Neurodegeneration
Subjects:
Pathological tau
Synaptic dysfunction
Synaptic plasticity
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s40035-021-00270-1

Internet

https://doi.org/10.1186/s40035-021-00270-1

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