Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics

Abstract Engineered T cells have emerged as highly effective treatments for hematological cancers. Hundreds of clinical programs are underway in efforts to expand the efficacy, safety, and applications of this immuno-therapeutic modality. A primary challenge in developing these “living drugs” is the...

Full description

Bibliographic Details
Main Authors: Daniel C. Kirouac, Cole Zmurchok, Denise Morris
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-024-00355-3