Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics
Abstract Engineered T cells have emerged as highly effective treatments for hematological cancers. Hundreds of clinical programs are underway in efforts to expand the efficacy, safety, and applications of this immuno-therapeutic modality. A primary challenge in developing these “living drugs” is the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
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| Series: | npj Systems Biology and Applications |
| Online Access: | https://doi.org/10.1038/s41540-024-00355-3 |
| _version_ | 1827310148975067136 |
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| author | Daniel C. Kirouac Cole Zmurchok Denise Morris |
| author_facet | Daniel C. Kirouac Cole Zmurchok Denise Morris |
| author_sort | Daniel C. Kirouac |
| collection | DOAJ |
| description | Abstract Engineered T cells have emerged as highly effective treatments for hematological cancers. Hundreds of clinical programs are underway in efforts to expand the efficacy, safety, and applications of this immuno-therapeutic modality. A primary challenge in developing these “living drugs” is the complexity of their pharmacology, as the drug product proliferates, differentiates, traffics between tissues, and evolves through interactions with patient immune systems. Using publicly available clinical data from Chimeric Antigen Receptor (CAR) T cells, we demonstrate how mathematical models can be used to quantify the relationships between product characteristics, patient physiology, pharmacokinetics and clinical outcomes. As scientists work to develop next-generation cell therapy products, mathematical models will be integral for contextualizing data and facilitating the translation of product designs to clinical strategy. |
| first_indexed | 2024-04-24T19:55:00Z |
| format | Article |
| id | doaj.art-7660ff3942e2485fb9cd34c89b012eeb |
| institution | Directory Open Access Journal |
| issn | 2056-7189 |
| language | English |
| last_indexed | 2024-04-24T19:55:00Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Systems Biology and Applications |
| spelling | doaj.art-7660ff3942e2485fb9cd34c89b012eeb2024-03-24T12:24:32ZengNature Portfolionpj Systems Biology and Applications2056-71892024-03-0110111310.1038/s41540-024-00355-3Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeuticsDaniel C. Kirouac0Cole Zmurchok1Denise Morris2Notch TherapeuticsNotch TherapeuticsEmerald City Pharma ConsultingAbstract Engineered T cells have emerged as highly effective treatments for hematological cancers. Hundreds of clinical programs are underway in efforts to expand the efficacy, safety, and applications of this immuno-therapeutic modality. A primary challenge in developing these “living drugs” is the complexity of their pharmacology, as the drug product proliferates, differentiates, traffics between tissues, and evolves through interactions with patient immune systems. Using publicly available clinical data from Chimeric Antigen Receptor (CAR) T cells, we demonstrate how mathematical models can be used to quantify the relationships between product characteristics, patient physiology, pharmacokinetics and clinical outcomes. As scientists work to develop next-generation cell therapy products, mathematical models will be integral for contextualizing data and facilitating the translation of product designs to clinical strategy.https://doi.org/10.1038/s41540-024-00355-3 |
| spellingShingle | Daniel C. Kirouac Cole Zmurchok Denise Morris Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics npj Systems Biology and Applications |
| title | Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics |
| title_full | Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics |
| title_fullStr | Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics |
| title_full_unstemmed | Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics |
| title_short | Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics |
| title_sort | making drugs from t cells the quantitative pharmacology of engineered t cell therapeutics |
| url | https://doi.org/10.1038/s41540-024-00355-3 |
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