The Combined Inhibition of Autophagy and Diacylglycerol Acyltransferase-Mediated Lipid Droplet Biogenesis Induces Cancer Cell Death during Acute Amino Acid Starvation

The Combined Inhibition of Autophagy and Diacylglycerol Acyltransferase-Mediated Lipid Droplet Biogenesis Induces Cancer Cell Death during Acute Amino Acid Starvation

Lipid droplets (LDs) are dynamic organelles involved in the management of fatty acid trafficking and metabolism. Recent studies suggest that autophagy and LDs serve complementary roles in the protection against nutrient stress, but the autophagy–LD interplay in cancer cells is not well understood. H...

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Bibliographic Details
Main Authors: Maida Jusović, Pia Starič, Eva Jarc Jovičić, Toni Petan
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
lipid droplets
autophagy
nutrient starvation
diacylglycerol acyltransferase
cell death
cancer
Online Access:https://www.mdpi.com/2072-6694/15/19/4857

Internet

https://www.mdpi.com/2072-6694/15/19/4857

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