Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes

Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes

Programmable, RNA-guided nucleases are diverse enzymes that have been repurposed for biotechnological applications. Here, the authors mine an extensive genome-resolved metagenomics database and identified uncharacterized families of RNA-guided, compact nucleases.

Bibliographic Details
Main Authors: Daniela S. Aliaga Goltsman, Lisa M. Alexander, Jyun-Liang Lin, Rodrigo Fregoso Ocampo, Benjamin Freeman, Rebecca C. Lamothe, Andres Perez Rivas, Morayma M. Temoche-Diaz, Shailaja Chadha, Natalie Nordenfelt, Owen P. Janson, Ian Barr, Audra E. Devoto, Gregory J. Cost, Cristina N. Butterfield, Brian C. Thomas, Christopher T. Brown
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35257-7

Internet

https://doi.org/10.1038/s41467-022-35257-7

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