Synthesis and biological evaluation of 125I-erythropoietin as a potential radiopharmaceutical agent for tumours

Synthesis and biological evaluation of 125I-erythropoietin as a potential radiopharmaceutical agent for tumours

Erythropoietin (EPO) is a glycoprotein hormone responsible for regulating erythropoiesis. Expression of EPO and EPO receptors (EPOr) has recently been demonstrated in some neoplastic cell lines and tumours, suggesting a potential new target for therapy. In this work, EPO was labeled with iodine-125...

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Bibliographic Details
Main Authors: Gonçalo dos Santos Clemente, Vera Lúcia Serra Duarte
Format: Article
Language:English
Published: Universidade de São Paulo 2011-03-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Eritropoetina
Hormônio glicoprotéico
125I-erythropoietin
Eritropoese
Iodo-125
Tumores expressores de EPO
Erythropoietin (EPO)
Glycoprotein hormone
Erythropoiesis
Radiopharmaceuticals
Iodine-125
EPO expressive tumours
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100010

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100010

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