A hyperthermic seizure unleashes a surge of spreading depolarizations in Scn1a-deficient mice
Spreading depolarization (SD) is a massive wave of cellular depolarization that slowly migrates across the brain gray matter. Cortical SD is frequently generated following brain injury, while less is understood about its potential contribution to genetic disorders of hyperexcitability, such as SCN1A...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Clinical investigation
2023-08-01
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| Series: | JCI Insight |
| Subjects: | |
| Online Access: | https://doi.org/10.1172/jci.insight.170399 |