The effects of tidal volume size and driving pressure levels on pulmonary complement activation: an observational study in critically ill patients

The effects of tidal volume size and driving pressure levels on pulmonary complement activation: an observational study in critically ill patients

Abstract Background Mechanical ventilation can induce or even worsen lung injury, at least in part via overdistension caused by too large volumes or too high pressures. The complement system has been suggested to play a causative role in ventilator-induced lung injury. Aims and methods This was a si...

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Bibliographic Details
Main Authors: Friso M. de Beer, Luuk Wieske, Gerard van Mierlo, Diana Wouters, Sacha Zeerleder, Lieuwe D. Bos, Nicole P. Juffermans, Marcus J. Schultz, Tom van der Poll, Wim K. Lagrand, Janneke Horn, for the BASIC–study group
Format: Article
Language:English
Published: SpringerOpen 2020-12-01
Series:Intensive Care Medicine Experimental
Subjects:
Intensive care
Critical care
Mechanical ventilation
Tidal volume
Driving pressure
Bronchoalveolar lavage
Online Access:https://doi.org/10.1186/s40635-020-00356-6

Internet

https://doi.org/10.1186/s40635-020-00356-6

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