Constitutive or Induced HIF-2 Addiction is Involved in Resistance to Anti-EGFR Treatment and Radiation Therapy in HNSCC

Constitutive or Induced HIF-2 Addiction is Involved in Resistance to Anti-EGFR Treatment and Radiation Therapy in HNSCC

Background: management of head and neck squamous cell carcinomas (HNSCC) include anti-Epidermal Growth Factor Receptor (EGFR) antibodies and radiotherapy, but resistance emerges in most patients. <i>RAS</i> mutations lead to primary resistance to EGFR blockade in metastatic colorectal ca...

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Bibliographic Details
Main Authors: Pierre Coliat, Ludivine Ramolu, Jérémie Jégu, Christian Gaiddon, Alain C. Jung, Erwan Pencreach
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
head and neck squamous cell carcinoma
anti-egfr targeted therapy
resistance
oncogenic addiction
hif-2α
Online Access:https://www.mdpi.com/2072-6694/11/10/1607

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https://www.mdpi.com/2072-6694/11/10/1607

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