The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models

The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models

Arterial flow regulates artery diameter but other mechanisms may also affect this. Here, the authors show that the guanine nucleotide exchange factor Trio and GTPases Rac1 and RhoG, triggers F-actin remodeling in arterial endothelial cells, independent of flow, to enhance lumen diameter in zebrafish...

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Bibliographic Details
Main Authors: Alina Klems, Jos van Rijssel, Anne S. Ramms, Raphael Wild, Julia Hammer, Melanie Merkel, Laura Derenbach, Laetitia Préau, Rabea Hinkel, Irina Suarez-Martinez, Stefan Schulte-Merker, Ramon Vidal, Sascha Sauer, Riikka Kivelä, Kari Alitalo, Christian Kupatt, Jaap D. van Buul, Ferdinand le Noble
Format: Article
Language:English
Published: Nature Portfolio 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19008-0

Internet

https://doi.org/10.1038/s41467-020-19008-0

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