The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models
Arterial flow regulates artery diameter but other mechanisms may also affect this. Here, the authors show that the guanine nucleotide exchange factor Trio and GTPases Rac1 and RhoG, triggers F-actin remodeling in arterial endothelial cells, independent of flow, to enhance lumen diameter in zebrafish...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19008-0 |
| _version_ | 1819259985007214592 |
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| author | Alina Klems Jos van Rijssel Anne S. Ramms Raphael Wild Julia Hammer Melanie Merkel Laura Derenbach Laetitia Préau Rabea Hinkel Irina Suarez-Martinez Stefan Schulte-Merker Ramon Vidal Sascha Sauer Riikka Kivelä Kari Alitalo Christian Kupatt Jaap D. van Buul Ferdinand le Noble |
| author_facet | Alina Klems Jos van Rijssel Anne S. Ramms Raphael Wild Julia Hammer Melanie Merkel Laura Derenbach Laetitia Préau Rabea Hinkel Irina Suarez-Martinez Stefan Schulte-Merker Ramon Vidal Sascha Sauer Riikka Kivelä Kari Alitalo Christian Kupatt Jaap D. van Buul Ferdinand le Noble |
| author_sort | Alina Klems |
| collection | DOAJ |
| description | Arterial flow regulates artery diameter but other mechanisms may also affect this. Here, the authors show that the guanine nucleotide exchange factor Trio and GTPases Rac1 and RhoG, triggers F-actin remodeling in arterial endothelial cells, independent of flow, to enhance lumen diameter in zebrafish and cell models. |
| first_indexed | 2024-12-23T19:18:42Z |
| format | Article |
| id | doaj.art-766d4ed327d94a5ba84fee477abb7f31 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T19:18:42Z |
| publishDate | 2020-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-766d4ed327d94a5ba84fee477abb7f312022-12-21T17:34:15ZengNature PortfolioNature Communications2041-17232020-10-0111112010.1038/s41467-020-19008-0The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell modelsAlina Klems0Jos van Rijssel1Anne S. Ramms2Raphael Wild3Julia Hammer4Melanie Merkel5Laura Derenbach6Laetitia Préau7Rabea Hinkel8Irina Suarez-Martinez9Stefan Schulte-Merker10Ramon Vidal11Sascha Sauer12Riikka Kivelä13Kari Alitalo14Christian Kupatt15Jaap D. van Buul16Ferdinand le Noble17Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT)Molecular Cell Biology lab, Department Molecular and Cellular Hemostasis, Sanquin Research and Landsteiner Laboratory, Academic Medical Center at the University of AmsterdamDepartment of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT)Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT)Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT)Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT)Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT)Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT)Laboratory Animal Science Unit, Leibnitz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, Kellnerweg 4, 37077 Göttingen, Germany and DZHK (German Center for Cardiovascular Research)Institute of Cardiovascular Organogenesis and Regeneration WWU Münster, Münster, Germany & Faculty of Medicine, WWU Münster, Münster, Germany & Cells in Motion Cluster of Excellence, MünsterInstitute of Cardiovascular Organogenesis and Regeneration WWU Münster, Münster, Germany & Faculty of Medicine, WWU Münster, Münster, Germany & Cells in Motion Cluster of Excellence, MünsterMax Delbrück Center for Molecular Medicine (MDC), Berlin Institute of Medical Systems Biology & Berlin Institute of HealthMax Delbrück Center for Molecular Medicine (MDC), Berlin Institute of Medical Systems Biology & Berlin Institute of HealthStem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, and Wihuri Research InstituteTranslational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, and Wihuri Research InstituteKlinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, TUM Munich, Germany, and DZHK, (German Center for Cardiovascular Research)Molecular Cell Biology lab, Department Molecular and Cellular Hemostasis, Sanquin Research and Landsteiner Laboratory, Academic Medical Center at the University of AmsterdamDepartment of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT)Arterial flow regulates artery diameter but other mechanisms may also affect this. Here, the authors show that the guanine nucleotide exchange factor Trio and GTPases Rac1 and RhoG, triggers F-actin remodeling in arterial endothelial cells, independent of flow, to enhance lumen diameter in zebrafish and cell models.https://doi.org/10.1038/s41467-020-19008-0 |
| spellingShingle | Alina Klems Jos van Rijssel Anne S. Ramms Raphael Wild Julia Hammer Melanie Merkel Laura Derenbach Laetitia Préau Rabea Hinkel Irina Suarez-Martinez Stefan Schulte-Merker Ramon Vidal Sascha Sauer Riikka Kivelä Kari Alitalo Christian Kupatt Jaap D. van Buul Ferdinand le Noble The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models Nature Communications |
| title | The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models |
| title_full | The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models |
| title_fullStr | The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models |
| title_full_unstemmed | The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models |
| title_short | The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models |
| title_sort | gef trio controls endothelial cell size and arterial remodeling downstream of vegf signaling in both zebrafish and cell models |
| url | https://doi.org/10.1038/s41467-020-19008-0 |
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