Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study

Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study

Abstract Background In addition to decreasing the level of cholesterol, proprotein convertase subtilis kexin 9 (PCSK9) inhibitor has pleiotropic effects, including immune regulation. However, the impact of PCSK9 on autoimmune diseases is controversial. Therefore, we used drug target Mendelian random...

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Bibliographic Details
Main Authors: Weijia Xie, Jiaxin Li, Hao Du, Jian Xia
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Arthritis Research & Therapy
Subjects:
Drug-target Mendelian randomization
PCSK9
HMGCR
Autoimmune disease
Immune regulation
Online Access:https://doi.org/10.1186/s13075-023-03122-7

Internet

https://doi.org/10.1186/s13075-023-03122-7

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