6-Gingerol alleviates placental injury in preeclampsia by inhibiting oxidative stress via BNIP3/LC3 signaling-mediated trophoblast mitophagy

6-Gingerol alleviates placental injury in preeclampsia by inhibiting oxidative stress via BNIP3/LC3 signaling-mediated trophoblast mitophagy

Background and aims: Preeclampsia (PE) is the leading cause of maternal and fetal morbidity and mortality worldwide. Apoptosis of trophoblast cells induced by oxidative stress is a principal reason of placental injury in PE. 6-Gingerol, an antioxidant from ginger, plays an important role in many dis...

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Bibliographic Details
Main Authors: Anna Li, Man Zhao, Zexin Yang, Zhenya Fang, Weiyi Qi, Changqing Zhang, Meijuan Zhou, Junjun Guo, Shuxian Li, Xietong Wang, Meihua Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Pharmacology
Subjects:
6-gingerol
preeclampsia
mitophagy
trophoblast
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1243734/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1243734/full

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