The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity.

The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity.

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Hepatitis C virus (HCV) exploits the four entry factors CD81, scavenger receptor class B type I (SR-BI, also known as SCARB1), occludin, and claudin-1 as well as the co-factor epidermal growth factor receptor (EGFR) to infect human hepatocytes. Here, we report that the disintegrin and matrix metallo...

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Bibliographic Details
Main Authors: Belén Carriquí-Madroñal, Julie Sheldon, Mara Duven, Cora Stegmann, Karsten Cirksena, Emanuel Wyler, Francisco J Zapatero-Belinchón, Florian W R Vondran, Gisa Gerold
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-11-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011759&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011759&type=printable

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