Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1

Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1

Abstract Background The function of mesenchymal stem cells (MSCs) from patients with osteoporosis (OP) is impaired and worsens in patients with type 2 diabetes mellitus (T2DM). Icariin (ICA) is the major active flavonoid glucoside isolated from traditional Chinese herbal Epimedium pubescens, and con...

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Bibliographic Details
Main Authors: Sheng-li Xia, Zi-yuan Ma, Bin Wang, Feng Gao, Sheng-yang Guo, Xu-han Chen
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Icariin
T2DM
GLI-1
Osteogenic differentiation
Osteoporosis
Online Access:https://doi.org/10.1186/s13018-023-03998-w

Internet

https://doi.org/10.1186/s13018-023-03998-w

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