The Refsum disease marker phytanic acid, a branched chain fatty acid, affects Ca2+ homeostasis and mitochondria, and reduces cell viability in rat hippocampal astrocytes

The Refsum disease marker phytanic acid, a branched chain fatty acid, affects Ca2+ homeostasis and mitochondria, and reduces cell viability in rat hippocampal astrocytes

The saturated branched chain fatty acid, phytanic acid, a degradation product of chlorophyll, accumulates in Refsum disease, an inherited peroxisomal disorder with neurological clinical features. To elucidate the pathogenic mechanism, we investigated the influence of phytanic acid on cellular physio...

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Bibliographic Details
Main Authors: Stefan Kahlert, Peter Schönfeld, Georg Reiser
Format: Article
Language:English
Published: Elsevier 2005-02-01
Series:Neurobiology of Disease
Subjects:
Refsum disease
Peroxisomal disorder
Phytanic acid
Mitochondrial potential
Mitochondrial permeability transition pore
Cytosolic calcium
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001974

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http://www.sciencedirect.com/science/article/pii/S0969996104001974

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